Preparation and Optimization of Esomeprazole Nanosuspension using Evaporative Precipitation– Ultrasonication

Preparation and Optimization of Esomeprazole Nanosuspension using Evaporative Precipitation– Ultrasonication

Purpose: To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Esomeprazole nanosuspensions were prepared by evaporative precipitation-ultrasonication method using F68 (Poloxamer 188) and F127 (Poloxamer 407) as stabilizers. Formulation and process variables (concentration of stabilizers and drug, power input and duration of ultrasonication) affecting th...

Fabrication of Nanoparticles of Silymarin, Hesperetin and Glibenclamide by Evaporative Precipitation of Nanosuspension for Fast Dissolution

Evaporative precipitation of nanosuspension (EPN) was used to prepare nanoparticles of poorly water soluble drugs, namely silymarin (SLM), hesperetin (HSP) and glibenclamide (GLB), with the aim of improving their rate of dissolution. The original drugs and EPN prepared drug nanoparticles were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and dissol...

preparation, optimization and in vitro characterization of nanosuspension of cyclosporine

Preparation and optimization of acetaminophen nanosuspension through nanoprecipitation using microfluidic devices: an artificial neural networks study.

The purpose of this study was to find an artificial neural networks model for determining major factors impacting the stability of an acetaminophen nanosuspansion that was prepared using nanoprecipitation in microfluidic reactors. Four variables, namely concentration of surfactant, solvent and antisolvent flow rate and solvent temperature were used as input variables and time of sedimentation o...

preparation, optimization and in vitro characterization of nanosuspension of orlistat